Ehlabathini lophuhliso lwamachiza kunye ne-pharmacokinetics, ukubaluleka kokusetyenziswa kweekhithi zophando ezithembekileyo neziphezulu azikwazi ukugqithiswa. Enye yezo mveliso ziyimfuneko yikiti ye-microsomes yesibindi somntu, edlala indima ebalulekileyo ekulinganisweni kweenkqubo zemetabolism yabantu. Kwi-IPHASE, sisebenza ngokukhethekileyo ekuboneleleni ngeentlobo ezahlukeneyo zeemveliso zophando lwesayensi yobomi, kubandakanywa nekhithi ye-microsomes yesibindi somntu, eyenzelwe ukuxhasa abaphandi kwimfuno yabo yokuqhubela phambili kwezonyango.
I-IPHASE yaqala uhambo lwayo ngokuzisa i-ADME yayo yokuqala (i-Absorption, Distribution, Metabolism, kunye ne-Excretion) iimveliso ezijolise ekuphuculeni iinkqubo zokuhlola iziyobisi kwangaphambili. Ukutyhubela iminyaka yophando oluzinikeleyo kunye nophuhliso, siye sandisa kakhulu iminikelo yethu, siqinisekisa ukuba abathengi bethu banokufikelela kwizixhobo ezikumgangatho ophezulu kuzo zonke iinkalo ezahlukeneyo, kubandakanya i-pharmacokinetics, i-pharmacology, i-microbiology, i-immunology, i-genetics, kunye neyeza lonyango. Ukuzibophelela kwethu ekugqweseni kuyabonakala kwipotifoliyo yethu ebanzi, ngoku ebandakanya ngaphezulu kwe-2,000 yeemveliso eziphuhliswe ngokwazo ukusuka kunikezelo lwenkcubeko yeeseli ukuya kwiikiti zovavanyo lwe-genotoxicity.
Ikhithi ye-microsomes yesibindi somntu sisixhobo esibalulekileyo kwizifundo ze-pharmacokinetic, ngakumbi xa kufikwa ekuqondeni uzinzo lwe-metabolic yabaviwa bamachiza. Le kit yenza abaphandi bavavanye iinkqubo ze-metabolic ezenziwa ngamachiza kwisibindi somntu, ukuvavanya izinto ezifana nomsebenzi we-enzyme kunye nokubunjwa kwe-metabolites. Ngokusebenzisa ikiti yethu ye-microsomes yesibindi somntu, izazinzulu zinokuqikelela ngokuchanekileyo ukuba iikhompawundi zazo ziya kuziphatha njani emzimbeni womntu, zivumela ukwenziwa kwezigqibo ezinolwazi ekuphuhliseni amachiza kunye nokuqulunqwa.
Kwi-IPHASE, siyazingca ngokuqinisekiswa kweemveliso zethu ngokuchasene nemigangatho yangaphakathi kunye nehlabathi jikelele, kubandakanywa nezikhokelo ze-OECD kunye ne-ICH. Oku kuzibophelela kuqinisekisa ukuba ikiti yethu ye-microsomes yesibindi somntu kunye nezinye izibonelelo zihlangabezana nemigangatho ephezulu yomgangatho, ukubonelela ngeziphumo ezithembekileyo kunye nokuveliswa kwakhona kubaxhasi bethu. Ngaphaya koko, iimveliso zethu zifumene isiqinisekiso kunye nezatifikethi zelungelo elilodwa lomenzi wechiza, kunye nokuqondwa ngokubanzi koogxa bethu kwishishini, siqinisa isidima sethu njengomthengisi othembekileyo kwicandelo lezenzululwazi zobomi.
Ukongeza kwikiti yethu ye-microsomes yesibindi somntu, uluhlu lwethu lweemveliso ezahlukeneyo lubandakanya iikiti ezikhethekileyo ezifana ne-high-quality IPHASE monkey (Cynomolgus) i-plasma kit, i-minipig yonke ikiti yokuqokelela igazi, kunye nezinye izixhobo ezahlukeneyo ezilungiselelwe iimfuno ezithile zophando. Olu luhlu lubanzi lweminikelo luvumela abathengi bethu ukuba bakhethe ezona mveliso zifanelekileyo kwiinjongo zabo zophando, ekugqibeleni baphucule ukusebenza kakuhle kunye neziphumo zezifundo zabo.
Kwi-IPHASE, siyaqonda ukuba impumelelo yabathengi bethu ixhomekeke kumgangatho wezixhobo zophando abazisebenzisayo. Yiyo loo nto siqhubeka senza utyalo-mali kuphando lwemveliso kunye nophuhliso ngelixa sibonelela ngenkxaso ekhethekileyo emva kokuthengisa ukuqinisekisa ukuba abathengi bethu banokulonyusa ixabiso leemveliso zethu, kubandakanya ikiti ye-microsomes yesibindi somntu. Iqela lethu elizinikeleyo leengcaphephe lihlala likhona ukunceda abathengi ekukhetheni iimveliso ezifanelekileyo kwiimfuno zabo ezithile kunye nokubonelela ngesikhokelo malunga neendlela ezifanelekileyo zokulandela ngexesha lovavanyo.
Ukuqukumbela, ikiti ye-microsomes yesibindi somntu yi-asethi exabisekileyo kubaphandi abajonga kwimetabolism yeziyobisi kunye ne-pharmacokinetics. Ukuzibophelela okungagungqiyo kwe-IPHASE kumgangatho kunye nokusungula izinto ezintsha kusibeka njengababoneleli abakhokelayo kwishishini lezesayensi zobomi. Phonononga uluhlu lwethu olubanzi lweemveliso namhlanje kwaye ube namava umahluko onokwenziwa zizixhobo zophando ezikumgangatho ophezulu kwiinzame zakho zenzululwazi.
