Munyika yekuvandudzwa kwezvinodhaka uye pharmacokinetics, kukosha kwekushandisa yakavimbika uye yepamusoro-soro kits yekutsvagisa haigone kuwedzeredzwa. Chimwe chakadaro chakakosha chigadzirwa chiropa chemunhu microsomes kit, icho chinoita basa rakakosha mukuenzanisa maitiro emetabolic evanhu. PaIPHASE, isu tine hunyanzvi mukupa akasiyana siyana ehupenyu sainzi zvigadzirwa, zvinosanganisira chiropa chemunhu microsomes kit, yakagadzirirwa kutsigira vaongorori mukuda kwavo kufambira mberi kwekurapa.
IPHASE yakatanga rwendo rwayo nekuunza yayo yekutanga ADME (Absorption, Distribution, Metabolism, uye Excretion) zvigadzirwa zvine chinangwa chekuvandudza maitiro ekutanga ekuongorora zvinodhaka. Kuburikidza nemakore ekutsvagisa kwakazvipira uye budiriro, takawedzera zvakanyanya kupa kwedu, tichiona kuti vatengi vedu vanokwanisa kuwana ekucheka-kumucheto maturusi munzvimbo dzakasiyana siyana, kusanganisira pharmacokinetics, pharmacology, microbiology, immunology, genetics, uye mushonga wekiriniki. Kuzvipira kwedu kuita zvakanaka kunoonekwa mune yedu yakakura portfolio, iyo ikozvino inosanganisira zvinopfuura zviuru zviviri zvezvigadziriso zvega kubva pasero tsika zvinopihwa kune genotoxicity test kits.
Chiropa chemunhu microsomes kit chishandiso chakakosha chezvidzidzo zvepharmacokinetic, kunyanya kana zvasvika pakunzwisisa kugadzikana kwemetabolism yevanoda zvinodhaka. Iyi kit inogonesa vaongorori kuti vaongorore metabolic maitiro ayo zvinodhaka anopinda muchiropa chemunhu, achiongorora zvinhu zvakaita sekuita kwe enzyme uye kuumbwa kwematabolites. Nekushandisa yedu yemunhu chiropa microsomes kit, masayendisiti anogona kufanotaura nemazvo kuti makomisheni avo achaita sei mumuviri wemunhu, zvichibvumira kuita sarudzo ine ruzivo mukuvandudza nekugadzira zvinodhaka.
PaIPHASE, tinodada nekusimbiswa kwezvigadzirwa zvedu zvichipesana nemukati-mumba neyepasi rose zviyero, kusanganisira iyo OECD neICH nhungamiro. Kuzvipira uku kunovimbisa kuti chiropa chedu chemunhu microsomes kit uye zvimwe zvinopihwa zvinosangana nemhando yepamusoro zviyero, zvichipa yakavimbika uye inobereka mhedzisiro kune vatengi vedu. Uyezve, zvigadzirwa zvedu zvakagamuchira zvitupa uye patent zvitupa, pamwe nekuzivikanwa kwakakura kubva kune vezera reindasitiri, kusimbisa mukurumbira wedu semutengesi akavimbika muchikamu chesainzi yehupenyu.
Kuwedzera kune yedu yemunhu chiropa microsomes kit, yedu yezvigadzirwa zvakasiyana siyana inosanganisira emhando yepamusoro IPHASE monkey (Cynomolgus) plasma kit, minipig yese yekuunganidza ropa kit, uye mamwe akasiyana maturusi akagadzirirwa zvakanangana netsvakiridzo zvinodiwa. Izvi zvakapamhama zvezvipo zvinobvumira vatengi vedu kuti vasarudze zvigadzirwa zvakanyanyokodzera zvezvinangwa zvavo zvekutsvagisa, pakupedzisira vachiwedzera kugona uye nemhedzisiro yezvidzidzo zvavo.
PaIPHASE, tinonzwisisa kuti kubudirira kwevatengi vedu kunoenderana nemhando yezvishandiso zvekutsvaga zvavanoshandisa. Ndosaka tiri kuramba tichidyara mari mukutsvagisa chigadzirwa uye kusimudzira tichipa yakasarudzika-yekutengesa-rutsigiro kuti tive nechokwadi chekuti vatengi vedu vanogona kukwirisa kukosha kwezvigadzirwa zvedu, kusanganisira chiropa chemunhu microsomes kit. Chikwata chedu chakazvipira chenyanzvi chinogara chiripo kubatsira vatengi mukusarudza zvigadzirwa zvakafanira kune zvavanoda chaizvo uye nekupa gwara pane zvakanakisa maitiro ekutevera panguva yekuyedza.
Mukupedzisa, chiropa chemunhu microsomes kit chinhu chakakosha chevaongorori vari kuongorora zvinodhaka metabolism uye pharmacokinetics. Kuzvipira kusingazununguki kweIPHASE kumhando uye hunyanzvi hunotiisa isu sevanotungamira mupi muindasitiri yesainzi yehupenyu. Ongorora huwandu hwedu hwakakura hwezvigadzirwa nhasi uye unzwe mutsauko unogona kuitwa emhando yepamusoro maturusi ekutsvagisa mukuedza kwako kwesainzi.
