Mwisi yiterambere ryibiyobyabwenge na farumasi, akamaro ko gukoresha ibikoresho byizewe kandi byujuje ubuziranenge ntibishobora kuvugwa. Kimwe mu bicuruzwa nkenerwa ni ibikoresho bya microsomes yumwijima wumuntu, bigira uruhare runini mukwigana imikorere ya metabolike yabantu. Muri IPHASE, tuzobereye mugutanga ibintu byinshi bitandukanye byubushakashatsi bwa siyanse yubuzima, harimo ibikoresho bya microsomes yumwijima byabantu, byagenewe gufasha abashakashatsi mugushakisha iterambere ryubuvuzi.
IPHASE yatangiye urugendo rwayo itangiza ADME yambere (Absorption, Ikwirakwizwa, Metabolism, na Excretion) igamije kunoza uburyo bwo gusuzuma ibiyobyabwenge hakiri kare. Binyuze mu myaka myinshi y'ubushakashatsi n'iterambere byabigenewe, twaguye cyane ibyo dutanga, tureba ko abakiriya bacu bafite ibikoresho bigezweho mu nzego zitandukanye, harimo nka farumasi, imiti, imiti, mikorobe, immunologiya, genetique, n'ubuvuzi. Ibyo twiyemeje kuba indashyikirwa bigaragarira mu nshingano zacu, ubu zirimo ibicuruzwa birenga 2000 byateje imbere ubwabyo kuva ku muco w’akagari kugeza ku bikoresho bipimisha genotoxicity.
Igikoresho cyumwijima microsomes yumuntu nigikoresho cyingenzi mubushakashatsi bwa farumasi, cyane cyane mugihe cyo gusobanukirwa ihinduka ryimikorere yabakandida ibiyobyabwenge. Iki gikoresho gifasha abashakashatsi gusuzuma inzira ya metabolike imiti ikorerwa mu mwijima wabantu, gusuzuma ibintu nkibikorwa bya enzyme no gukora metabolite. Mugukoresha ibikoresho bya microsomes yumwijima byabantu, abahanga barashobora guhanura neza uko ibice byabo bizitwara mumubiri wumuntu, bigatuma ibyemezo bifatwa neza mugutezimbere ibiyobyabwenge no kubitegura.
Kuri IPHASE, twishimiye kwemeza ibicuruzwa byacu binyuranyije n’imbere mu gihugu ndetse n’amahanga, harimo amabwiriza ya OECD na ICH. Iyi mihigo iremeza ko microsomes yumwijima wumuntu hamwe nibindi bitambo byujuje ubuziranenge bwo hejuru, bitanga ibisubizo byizewe kandi byororoka kubakiriya bacu. Byongeye kandi, ibicuruzwa byacu byabonye impamyabumenyi hamwe nimpamyabushobozi ya patenti, hamwe no kumenyekana cyane murungano rwinganda, bishimangira izina ryacu nkumuntu utanga isoko ryizewe mubuzima bwa siyanse yubuzima.
Usibye ibikoresho bya microsomes yumwijima byabantu, ibicuruzwa byacu bitandukanye birimo ibikoresho byabigenewe nkibikoresho byo mu rwego rwohejuru bya IPHASE inguge (Cynomolgus) plasma kit, minipig ibikoresho byose byo gukusanya amaraso, nibindi bikoresho bitandukanye bigenewe ubushakashatsi bwihariye. Ubu buryo bwagutse butanga abakiriya bacu guhitamo ibicuruzwa bibereye intego zabo zubushakashatsi, amaherezo bikazamura imikorere nibisubizo byubushakashatsi bwabo.
Kuri IPHASE, twumva ko intsinzi yabakiriya bacu biterwa nubwiza bwibikoresho byubushakashatsi bakoresha. Niyo mpamvu dukomeje gushora imari mubushakashatsi bwibicuruzwa no kwiteza imbere mugihe dutanga inkunga idasanzwe nyuma yo kugurisha kugirango tumenye neza ko abakiriya bacu bashobora kuzamura agaciro k'ibicuruzwa byacu, harimo na microsomes y'umwijima w'umuntu. Itsinda ryacu ryinzobere ryihari rirahari kugirango rifashe abakiriya guhitamo ibicuruzwa byiza kubyo bakeneye byihariye no gutanga ubuyobozi kubikorwa byiza byakurikizwa mugihe cyubushakashatsi.
Mu gusoza, ibikoresho byumwijima microsomes yumuntu numutungo ntagereranywa kubashakashatsi binjira mumiti ya metabolism na pharmacokinetics. Ubwitange bwa IPHASE butajegajega mubyiza no guhanga udushya biduha umwanya wambere mubatanga ubumenyi mubuzima. Shakisha ibicuruzwa byinshi muri iki gihe kandi wibonere itandukaniro ibikoresho byubushakashatsi bufite ireme bishobora gukora mubikorwa bya siyansi.
