M'dziko lachitukuko cha mankhwala ndi pharmacokinetics, kufunika kogwiritsa ntchito zida zofufuzira zodalirika komanso zapamwamba sizinganenedwe. Chimodzi mwazofunikira zotere ndi chida cha ma microsomes a chiwindi chamunthu, chomwe chimagwira ntchito yofunika kwambiri potengera kagayidwe kachakudya ka anthu. Ku IPHASE, timakhazikika popereka zinthu zosiyanasiyana zofufuza za sayansi ya moyo, kuphatikiza zida za microsomes m'chiwindi cha munthu, zomwe zidapangidwa kuti zithandizire ofufuza pakufuna kwawo kupita patsogolo kwamankhwala.
IPHASE idayamba ulendo wake pobweretsa zinthu zake zoyamba za ADME (Absorption, Distribution, Metabolism, and Excretion) zomwe cholinga chake ndi kukonza njira zowonera mankhwala. Kupyolera muzaka za kafukufuku wodzipereka ndi chitukuko, takulitsa kwambiri zopereka zathu, ndikuwonetsetsa kuti makasitomala athu ali ndi mwayi wogwiritsa ntchito zida zamakono m'magawo osiyanasiyana, kuphatikizapo pharmacokinetics, pharmacology, microbiology, immunology, genetics, ndi mankhwala azachipatala. Kudzipereka kwathu pakuchita bwino kwambiri kukuwonekera m'magawo athu ambiri, omwe tsopano akuphatikiza zinthu zopitilira 2,000 zopanga tokha, kuchokera kuzinthu zama cell kupita ku zida zoyesera za genotoxicity.
Chiwindi cha microsomes kit ndi chida chofunikira kwambiri pamaphunziro a pharmacokinetic, makamaka zikafika pakumvetsetsa kukhazikika kwa metabolic kwa omwe akufuna kumwa mankhwalawo. Chidachi chimathandizira ofufuza kuti awone momwe kagayidwe kazakudya kagayidwe kazakudya m'chiwindi cha munthu, kuwunika zinthu monga ma enzyme komanso mapangidwe a metabolites. Pogwiritsa ntchito zida zathu zama microsomes a chiwindi chamunthu, asayansi amatha kulosera molondola momwe mankhwalawo angakhalire m'thupi la munthu, ndikulola kupanga zisankho mozindikira pakupanga ndi kupanga mankhwala.
Ku IPHASE, timanyadira kutsimikizira kwazinthu zathu motsutsana ndi miyezo yapanyumba ndi yapadziko lonse lapansi, kuphatikiza malangizo a OECD ndi ICH. Kudzipereka kumeneku kumatsimikizira kuti zida zathu za microsomes pachiwindi chamunthu ndi zopereka zina zimakwaniritsa miyezo yapamwamba kwambiri, zomwe zimapereka zotsatira zodalirika komanso zobwereketsa kwa makasitomala athu. Kuphatikiza apo, zogulitsa zathu zalandira ziphaso zovomerezeka ndi zovomerezeka, komanso kuzindikirika kwakukulu kuchokera kwa anzawo amakampani, kulimbitsa mbiri yathu monga ogulitsa odalirika mu gawo la sayansi ya moyo.
Kuphatikiza pa zida zathu zama microsomes a chiwindi chamunthu, mitundu yathu yazinthu zosiyanasiyana imaphatikizapo zida zapadera monga zida zapamwamba za IPHASE nyani (Cynomolgus) plasma, zida zosonkhanitsira magazi a minipig, ndi zida zina zosiyanasiyana zopangidwira zosowa zapadera za kafukufuku. Zopereka zambirizi zimalola makasitomala athu kusankha zinthu zoyenera kwambiri pazolinga zawo zofufuza, ndipo pamapeto pake zimakulitsa luso komanso zotulukapo za maphunziro awo.
Ku IPHASE, timamvetsetsa kuti kupambana kwa makasitomala athu kumadalira mtundu wa zida zofufuzira zomwe amagwiritsa ntchito. Ichi ndichifukwa chake tikupitilizabe kuyika ndalama pakufufuza ndi chitukuko chazinthu pomwe tikupereka chithandizo chapadera pambuyo pogulitsa kuti tiwonetsetse kuti makasitomala athu atha kukulitsa mtengo wazinthu zathu, kuphatikiza zida zachiwindi chamunthu. Gulu lathu la akatswiri odzipatulira limakhalapo nthawi zonse kuti lithandize makasitomala posankha zinthu zoyenera pazosowa zawo komanso kupereka chitsogozo cha njira zabwino zomwe angatsatire panthawi yoyesera.
Pomaliza, zida za ma microsomes a chiwindi chamunthu ndi chinthu chamtengo wapatali kwa ofufuza omwe amafufuza kagayidwe ka mankhwala ndi pharmacokinetics. Kudzipereka kosasunthika kwa IPHASE pazabwino ndi zatsopano kumatipatsa mwayi wotsogolera pamakampani a sayansi ya moyo. Onani zinthu zathu zambirimbiri lero ndikuwona kusiyana komwe zida zapamwamba zofufuzira zingakupangitseni muzochita zanu zasayansi.
