Nyob rau hauv lub ntiaj teb no ntawm kev tsim tshuaj thiab pharmacokinetics, qhov tseem ceeb ntawm kev siv cov khoom siv tshawb fawb txhim khu kev qha thiab cov khoom siv zoo tshaj plaws tsis tuaj yeem hais ntau dhau. Ib yam khoom tseem ceeb no yog tib neeg lub siab microsomes cov khoom siv, uas ua lub luag haujlwm tseem ceeb hauv kev simulating tib neeg cov txheej txheem metabolic. Ntawm IPHASE, peb tshwj xeeb hauv kev muab ntau yam khoom siv tshawb fawb txog kev ua neej nyob, suav nrog tib neeg lub siab microsomes cov khoom siv, tsim los txhawb cov kws tshawb fawb hauv lawv txoj kev tshawb nrhiav kev kho mob.
IPHASE tau pib nws txoj kev taug los ntawm kev qhia nws thawj ADME (Kev nqus, Kev faib tawm, Metabolism, thiab Excretion) cov khoom siv txhawm rau txhim kho cov txheej txheem tshuaj xyuas thaum ntxov. Los ntawm kev mob siab rau kev tshawb fawb thiab kev tsim kho ntau xyoo, peb tau nthuav dav peb cov khoom lag luam, kom ntseeg tau tias peb cov neeg siv khoom tau nkag mus rau cov cuab yeej siv niaj hnub hla ntau yam xws li pharmacokinetics, pharmacology, microbiology, immunology, noob caj noob ces, thiab tshuaj kho mob. Peb txoj kev mob siab rau kev ua tau zoo yog pom tseeb hauv peb cov ntaub ntawv nthuav dav, uas tam sim no suav nrog ntau dua 2,000 tus kheej tsim cov khoom lag luam xws li cov khoom siv kab lis kev cai ntawm tes mus rau cov khoom siv kuaj genotoxicity.
Tib neeg lub siab microsomes cov khoom siv yog ib qho tseem ceeb rau kev tshawb fawb pharmacokinetic, tshwj xeeb tshaj yog thaum nws los nkag siab txog cov metabolism hauv kev ruaj ntseg ntawm cov neeg siv tshuaj. Cov khoom siv no tso cai rau cov kws tshawb fawb los soj ntsuam cov txheej txheem metabolic uas cov tshuaj tau nkag mus rau hauv tib neeg lub siab, tshuaj xyuas yam xws li kev ua enzyme thiab tsim cov metabolites. Los ntawm kev siv peb cov tib neeg lub siab microsomes cov khoom siv, cov kws tshawb fawb tuaj yeem kwv yees seb lawv cov tshuaj yuav coj li cas hauv tib neeg lub cev, tso cai rau kev txiav txim siab hauv kev tsim tshuaj thiab kev tsim.
Ntawm IPHASE, peb txaus siab rau qhov kev lees paub ntawm peb cov khoom tiv thaiv hauv tsev thiab thoob ntiaj teb cov qauv, suav nrog OECD thiab ICH cov lus qhia. Qhov kev cog lus no ua kom ntseeg tau tias peb cov tib neeg lub siab microsomes cov khoom siv thiab lwm yam khoom siv ua tau raws li cov qauv zoo tshaj plaws, muab cov txiaj ntsig txhim khu kev qha thiab rov tsim dua tshiab rau peb cov neeg siv khoom. Tsis tas li ntawd, peb cov khoom tau txais kev tsim nyog thiab patent daim ntawv pov thawj, nrog rau kev lees paub thoob plaws hauv kev lag luam cov phooj ywg, ua kom peb lub koob npe nrov ua tus neeg muag khoom ntseeg siab hauv kev tshawb fawb txog kev ua neej.
Ntxiv rau peb cov tib neeg lub siab microsomes cov khoom siv, peb cov khoom muaj ntau yam muaj xws li cov khoom siv tshwj xeeb xws li cov khoom siv zoo IPHASE liab (Cynomolgus) plasma kit, minipig tag nrho cov ntshav sau cov khoom siv, thiab ntau lwm yam cuab yeej haum rau kev tshawb fawb tshwj xeeb. Qhov kev nthuav dav dav no tso cai rau peb cov neeg siv khoom xaiv cov khoom tsim nyog tshaj plaws rau lawv cov hom phiaj kev tshawb fawb, thaum kawg txhim kho kev ua tau zoo thiab cov txiaj ntsig ntawm lawv cov kev tshawb fawb.
Ntawm IPHASE, peb nkag siab tias qhov kev vam meej ntawm peb cov neeg siv khoom yog nyob ntawm qhov zoo ntawm cov cuab yeej tshawb fawb uas lawv siv. Tias yog vim li cas peb tsis tu ncua nqis peev hauv cov khoom lag luam tshawb fawb thiab kev txhim kho thaum muab kev txhawb nqa tshwj xeeb tom qab muag kom ntseeg tau tias peb cov neeg siv khoom tuaj yeem ua kom muaj txiaj ntsig zoo ntawm peb cov khoom, suav nrog tib neeg lub siab microsomes cov khoom siv. Peb pab pawg kws tshaj lij yeej ib txwm muaj los pab cov neeg siv khoom xaiv cov khoom tsim nyog rau lawv cov kev xav tau tshwj xeeb thiab muab kev taw qhia txog kev coj ua zoo tshaj plaws los ua raws li kev sim.
Hauv kev xaus, tib neeg lub siab microsomes cov khoom siv yog ib qho khoom muaj nqis rau cov kws tshawb fawb delving rau hauv cov tshuaj metabolism thiab pharmacokinetics. IPHASE txoj kev cog lus tsis tu ncua rau kev ua tau zoo thiab kev tsim kho tshiab ua rau peb ua tus muab kev pabcuam hauv kev lag luam kev ua neej nyob. Tshawb nrhiav peb cov khoom siv dav dav niaj hnub no thiab paub txog qhov sib txawv uas cov cuab yeej tshawb fawb zoo tuaj yeem ua rau hauv koj qhov kev sim siab.
