I ka honua o ka hoʻomohala ʻana i ka lāʻau lapaʻau a me nā pharmacokinetics, ʻaʻole hiki ke hoʻohālikelike ʻia ke koʻikoʻi o ka hoʻohana ʻana i nā pahu noiʻi hilinaʻi a kiʻekiʻe. ʻO kekahi o ia huahana koʻikoʻi ʻo ia ka kit microsomes ate kanaka, kahi mea koʻikoʻi i ka hoʻohālikelike ʻana i nā kaʻina metabolic kanaka. Ma IPHASE, hoʻolalelale mākou i ka hoʻolako ʻana i nā ʻano huahana noiʻi ʻepekema ola, me ka kit microsomes ate kanaka, i hoʻolālā ʻia e kākoʻo i nā mea noiʻi i kā lākou ʻimi ʻana i nā holomua therapeutic.
Ua hoʻomaka ʻo IPHASE i kāna huakaʻi ma ka hoʻolauna ʻana i kāna mau huahana ADME (Absorption, Distribution, Metabolism, and Excretion) mua i manaʻo ʻia e hoʻomaikaʻi i nā kaʻina hana nānā lāʻau mua. Ma o nā makahiki o ka noiʻi hoʻolaʻa a me ka hoʻomohala ʻana, ua hoʻonui nui mākou i kā mākou mau makana, e hōʻoia i ka loaʻa ʻana o kā mākou mea kūʻai aku i nā mea hana ʻokiʻoki ma nā ʻano like ʻole, me ka pharmacokinetics, pharmacology, microbiology, immunology, genetics, a me ka lāʻau lapaʻau. ʻIke ʻia kā mākou kūpaʻa i ka maikaʻi i kā mākou kōpili nui, aia i kēia manawa ma luna o 2,000 mau huahana hoʻomohala ponoʻī mai nā lako moʻomeheu cell a hiki i nā pahu hoʻāʻo genotoxicity.
ʻO ka pahu microsomes ate kanaka he mea pono no ka noiʻi ʻana i ka lāʻau lapaʻau, ʻoi aku ka nui o ka hoʻomaopopo ʻana i ke kūpaʻa metabolic o nā moho lāʻau. Hāʻawi kēia kit i nā mea noiʻi e loiloi i nā kaʻina metabolic i loaʻa i nā lāʻau lapaʻau i loko o ke ake o ke kanaka, e loiloi i nā mea e like me ka hana enzyme a me ka hoʻokumu ʻana o nā metabolites. Ma ka hoʻohana ʻana i kā mākou kit microsomes ate, hiki i nā ʻepekema ke wānana pololei i ka hana ʻana o kā lākou pūhui i loko o ke kino kanaka, e ʻae ai i ka hoʻoholo ʻana i ka hoʻoholo ʻana i ka hoʻomohala ʻana a me ka hoʻokumu ʻana i ka lāʻau.
Ma IPHASE, haʻaheo mākou i ka hōʻoia ʻana o kā mākou huahana e kūʻē i nā kūlana kūloko a me ka honua, me nā alakaʻi OECD a me ICH. Ke hōʻoia nei kēia kūpaʻa i kā mākou kit microsomes ate kanaka a me nā makana ʻē aʻe e hoʻokō i nā kūlana kiʻekiʻe kiʻekiʻe, e hāʻawi ana i nā hopena hilinaʻi a reproducible no kā mākou mea kūʻai. Eia kekahi, ua loaʻa i kā mākou huahana nā palapala hōʻoia a me nā palapala patent, me ka ʻike ākea mai nā hoa ʻoihana, e hoʻoikaika ana i ko mākou inoa ma ke ʻano he mea hoʻolako hilinaʻi i ka ʻoihana ʻepekema ola.
Ma waho aʻe o kā mākou kit microsomes ate kanaka, ʻo kā mākou ʻano huahana like ʻole nā pahu kūikawā e like me ka kit plasma kiʻekiʻe IPHASE monkey (Cynomolgus), ka pahu hōʻiliʻili koko holoʻokoʻa minipig, a me nā mea hana ʻē aʻe i hana ʻia no nā pono noiʻi kikoʻī. ʻO kēia ākea ākea o nā hāʻawi e hiki ai i kā mākou mea kūʻai ke koho i nā huahana kūpono loa no kā lākou mau pahuhopu noiʻi, e hoʻonui ai i ka pono a me nā hopena o kā lākou noiʻi.
Ma IPHASE, maopopo mākou ʻo ka kūleʻa o kā mākou mea kūʻai aku e pili ana i ka maikaʻi o nā mea hana noiʻi a lākou e hoʻohana ai. ʻO ia ke kumu e hoʻomau mau nei mākou i ka noiʻi a me ka hoʻomohala ʻana i nā huahana me ka hāʻawi ʻana i ke kākoʻo ma hope o ke kūʻai ʻana e hōʻoia i hiki i kā mākou mea kūʻai ke hoʻonui i ka waiwai o kā mākou huahana, me ka kit microsomes ate kanaka. Loaʻa mau kā mākou hui loea e kōkua i nā mea kūʻai aku i ke koho ʻana i nā huahana kūpono no kā lākou pono kikoʻī a hāʻawi i ke alakaʻi i nā hana maikaʻi loa e hahai ai i ka wā hoʻokolohua.
I ka hopena, he waiwai koʻikoʻi ka kit microsomes ate kanaka no ka poʻe noiʻi e ʻimi ana i ka metabolism lāʻau a me nā pharmacokinetics. ʻO ka paʻa paʻa ʻole o IPHASE i ka maikaʻi a me ka hana hou e hoʻonoho iā mākou ma ke ʻano he alakaʻi alakaʻi i ka ʻoihana ʻepekema ola. E ʻimi i kā mākou ʻano huahana i kēia lā a ʻike i ka ʻokoʻa i hiki i nā mea hana noiʻi kiʻekiʻe ke hana i kāu mau ʻepekema.
